Vilon
Vilon (KE Dipeptide)
Vilon is a synthetic dipeptide (Lys-Glu, or KE) originally developed by the St. Petersburg Institute of Bioregulation and Gerontology as a bioregulator targeting the vascular system and connective tissue. It is primarily researched for its geroprotective properties, including regulation of vascular tone, improvement of microcirculation, and modulation of peptide bioregulators involved in aging. Vilon has been studied in both animal models and human clinical trials in Russia for conditions related to cardiovascular aging and immune senescence.
Mechanism of Action
Vilon acts as a short peptide bioregulator that penetrates cell nuclei and interacts with chromatin, modulating gene expression in endothelial and smooth muscle cells. It has been shown to normalize the synthesis of vascular wall components, upregulate antioxidant defense mechanisms, and influence the expression of proteins involved in cell proliferation and apoptosis. Its primary reported effect involves restoration of neurohumoral regulation of the vascular system and suppression of age-related changes in the transcriptome of vascular tissue.
Evidence by Health Goal(15 goals)
Dosing Protocols
Morning, subcutaneous or intramuscular injection
Cycle: 10 days on, followed by a break of 3–6 months; repeated 2–3 times per year
This is the primary protocol used in Russian clinical research. Typical course involves 10 consecutive daily injections. Reconstitute lyophilized powder in sterile bacteriostatic water.
Morning, held under tongue for 1–2 minutes before swallowing
Cycle: 10–20 days on, 3–6 month break; 2–3 cycles per year
Sublingual administration is used as an alternative to injection to improve convenience. Bioavailability may be lower than parenteral routes but is considered sufficient for bioregulatory effects by some researchers.
Safety & Side Effects
Vilon has a generally favorable safety profile in published Russian clinical studies, with no significant adverse events reported at physiological dose ranges; however, long-term safety data from large randomized controlled trials remain limited. It is not approved as a pharmaceutical agent by FDA or EMA, and is available primarily as a research compound, meaning quality and purity can vary significantly across vendors.
Possible Side Effects
- !Mild injection site redness or irritation with subcutaneous administration
- !Transient lightheadedness following administration, possibly related to vascular effects
- !Mild fatigue or lethargy in the initial days of a course
- !Rare hypersensitivity or allergic reaction to the peptide or excipients
- !Theoretical risk of overstimulation of cell proliferation with prolonged unsupervised use
Interactions
- -May potentiate the effects of antihypertensive medications due to its reported vasodilatory and vascular-normalizing properties — use caution and monitor blood pressure
- -Potential additive effects with other peptide bioregulators (e.g., Epithalon, Thymalin) — concurrent use is practiced empirically but lacks formal interaction studies
- -May theoretically enhance sensitivity to anticoagulants due to effects on endothelial function — use caution with warfarin or other blood thinners
- -Limited data on interaction with immunosuppressive drugs — given reported immune-modulating properties, caution is warranted in transplant patients or those on biologics
Cost & Where to Buy
Vilon is available from Russian pharmaceutical manufacturers (e.g., Peptide Bio) and international research peptide vendors. Cost reflects a 10-day course repeated 2–3 times per year; monthly equivalent is low. Price varies significantly by source, purity, and whether lyophilized vials or sublingual formats are purchased.
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