Prostatilen
Prostatilen (Prostate Bioregulator)
Prostatilen is a bovine prostate-derived peptide bioregulator (cytamine) developed in Russia, primarily used to support prostate gland function, reduce symptoms of benign prostatic hyperplasia (BPH), and improve male urogenital health. It contains a complex of biologically active peptides that exert tissue-specific regulatory effects on prostatic cells. It has been used clinically in Russia and Eastern Europe for decades as both a therapeutic and preventive agent for prostate disorders.
Mechanism of Action
Prostatilen works through a principle of tissue-specific peptide bioregulation, where short peptides derived from prostatic tissue are believed to bind to complementary DNA sequences in prostate cells, normalizing gene expression and cellular metabolism in dysfunctional or aging prostatic tissue. These peptides modulate inflammatory cytokines, reduce oxidative stress within glandular tissue, and help restore secretory and smooth muscle function of the prostate. Additionally, Prostatilen has demonstrated anti-inflammatory and mild anticoagulant properties by reducing prostaglandin synthesis and improving local microcirculation within the prostate.
Evidence by Health Goal(14 goals)
Dosing Protocols
Morning, intramuscular administration
Cycle: 10-day course, repeated 1-2 times per year
The standard clinical protocol is 10 daily intramuscular injections of 5mg per course. The lyophilized powder is reconstituted with 1-2mL of sterile water or saline. This is the primary evidence-based route used in clinical studies.
Rectal administration at bedtime after bowel emptying
Cycle: 10-day course, repeated 1-2 times per year
Rectal suppository form (Prostatilen-Zinc) provides local delivery with added zinc for additional androgenic and anti-inflammatory support. Preferred by patients who wish to avoid injections.
Safety & Side Effects
Prostatilen has a generally favorable safety profile when used in short 10-day courses at recommended doses, with decades of clinical use in Russia supporting its tolerability. However, individuals with bovine protein allergies should avoid it, and because it is derived from animal glandular tissue, quality control and pathogen screening of the source material are important safety considerations; it is available as a prescription or regulated product in Russia and is not approved by the FDA or EMA.
Possible Side Effects
- !Local injection site reactions including transient pain, redness, or swelling
- !Mild rectal discomfort or irritation with suppository use
- !Transient hypotension or lightheadedness due to vasodilatory effects
- !Mild allergic reactions including urticaria in sensitive individuals
- !Transient worsening of urinary symptoms at initiation of therapy
- !Nausea or gastrointestinal discomfort, primarily with high-dose regimens
- !Rare hypersensitivity reactions in individuals with bovine protein allergies
Interactions
- -May potentiate anticoagulant effects of warfarin or heparin due to its mild antiplatelet and fibrinolytic properties — monitor INR closely
- -Can enhance hypotensive effects of antihypertensive medications due to vasodilatory activity — use caution and monitor blood pressure
- -May interact additively with other prostate medications such as alpha-1 blockers (tamsulosin, doxazosin), potentially increasing risk of hypotension
- -Use with NSAIDs may have competing effects on prostaglandin pathways — theoretical reduction in efficacy of either agent
- -Not recommended concurrently with immunosuppressants due to its immunomodulatory peptide activity and unpredictable immune interactions
Cost & Where to Buy
Primarily sourced from Russian or Eastern European pharmaceutical suppliers and specialty peptide vendors. Injectable ampoule kits (10 x 5mg) range from $30-$60 per course; suppository formulations are similarly priced. Availability outside Russia is limited, which can increase cost due to import and shipping fees.
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