Hexarelin
Hexarelin (Examorelin)
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue (GHS) that potently stimulates endogenous growth hormone release. It is primarily investigated for its anabolic, cardioprotective, and GH-deficiency treatment applications, with research demonstrating efficacy in increasing IGF-1 levels and lean mass accrual.
Mechanism of Action
Hexarelin acts as a potent agonist at the growth hormone secretagogue receptor (GHSR-1a), also known as the ghrelin receptor, in the pituitary gland and hypothalamus, triggering robust GH pulse release. Unlike GHRH analogs, it also binds to CD36 scavenger receptors independently of the GHS pathway, contributing to its distinct cardioprotective effects including anti-fibrotic and anti-ischemic actions. The resulting GH surge elevates hepatic IGF-1 production, driving downstream anabolic and tissue-repair signaling.
Evidence by Health Goal(14 goals)
Dosing Protocols
On an empty stomach, ideally upon waking and/or 30-60 minutes before sleep
Cycle: 4-6 weeks on, 2-4 weeks off
Administered subcutaneously. Hexarelin exhibits more rapid desensitization of GHSR-1a than other GHS peptides, making cycling essential to preserve receptor sensitivity. Doses above 200mcg per injection do not appear to produce meaningfully greater GH release and increase side effect risk. Reconstitute with bacteriostatic water and refrigerate.
Safety & Side Effects
Hexarelin has a reasonably well-characterized short-term safety profile in human clinical studies, but long-term safety data are limited and it is not approved for therapeutic use in most jurisdictions, including the US, where it exists in a regulatory gray area as a research peptide. The prolactin and cortisol elevation with each dose is a meaningful concern with chronic use, and individuals with hormone-sensitive conditions, diabetes, or active malignancy should avoid use.
Possible Side Effects
- !Transient elevation in cortisol and prolactin levels following each injection
- !Water retention and mild edema due to GH-mediated effects
- !Increased appetite and hunger signaling via ghrelin pathway activation
- !Fatigue or lethargy, particularly with higher doses
- !Tingling or numbness in extremities (carpal tunnel-like symptoms with prolonged use)
- !Reduced insulin sensitivity with extended use at higher doses
- !Pituitary desensitization with continued use, reducing GH response over time
- !Injection site reactions including redness, soreness, or bruising
Interactions
- -May blunt the GH response when co-administered with somatostatin analogs (e.g., octreotide)
- -Synergistic GH release when combined with GHRH analogs (e.g., CJC-1295, Sermorelin) - can significantly amplify GH pulse, requiring dose reduction
- -May reduce insulin sensitivity, necessitating caution in individuals using insulin or oral hypoglycemic agents
- -Concurrent use with glucocorticoids may attenuate GH secretory response
- -Elevated prolactin may interact additively with dopamine antagonists (e.g., antipsychotics, metoclopramide), worsening hyperprolactinemia
Cost & Where to Buy
Pricing reflects research-grade peptide vendors supplying 2-5mg vials. A typical monthly supply at 100-200mcg once daily requires approximately 3-6mg. Cost varies significantly by vendor purity, third-party testing, and vial size purchased. Hexarelin is less widely stocked than GHRP-2 or GHRP-6, which can affect availability and price.
Search on Amazon