C-10
C-10 Peptide
C-10 is a short-chain peptide fragment derived from the C-terminus of thymosin alpha-1, investigated primarily for its immunomodulatory and potential anti-inflammatory properties. It has been explored in research contexts for immune system support, wound healing modulation, and as an adjunct in oncology research settings. Unlike the full thymosin alpha-1 sequence, C-10 represents a truncated fragment with potentially more targeted receptor interactions.
Mechanism of Action
C-10 peptide exerts its effects primarily by modulating T-cell maturation and differentiation through interactions with thymic epithelial receptors and downstream signaling cascades involving NF-κB and MAPK pathways. It may upregulate cytokine production—particularly IL-2 and interferon-gamma—thereby enhancing innate and adaptive immune responses. Additionally, C-10 has been studied for its ability to influence dendritic cell activation and natural killer cell cytotoxicity, suggesting a broad immunostimulatory mechanism.
Evidence by Health Goal(11 goals)
Dosing Protocols
Morning, on an empty stomach or at least 30 minutes before meals
Cycle: 8–12 weeks on, 4 weeks off
Administered subcutaneously, typically in the abdominal region. Reconstitute lyophilized powder with bacteriostatic water. Dose should be titrated based on individual immune status and research protocol. Clinical and human data are extremely limited; protocols are largely extrapolated from thymosin alpha-1 research.
Safety & Side Effects
C-10 peptide has a limited human clinical safety dataset, and most evidence is derived from preclinical studies or extrapolation from parent thymosin alpha-1 research; users should exercise significant caution and ideally consult with a physician before use. It is not approved by the FDA as a therapeutic agent and is currently classified as a research compound, meaning quality control across vendors may vary considerably.
Possible Side Effects
- !Mild injection site reactions including redness, swelling, or bruising
- !Transient fatigue or flu-like symptoms in the first 1–2 weeks of use
- !Low-grade fever during immune activation phase
- !Headache, particularly following initial doses
- !Nausea or mild gastrointestinal discomfort in sensitive individuals
- !Potential for autoimmune exacerbation in predisposed individuals
- !Allergic hypersensitivity reactions (rare but possible with peptide compounds)
Interactions
- -May potentiate the effects of immunosuppressant drugs (e.g., cyclosporine, tacrolimus), potentially reducing their efficacy
- -Concurrent use with corticosteroids may blunt the immunostimulatory effects of C-10
- -Use caution in combination with other immunomodulatory peptides (e.g., thymosin beta-4, LL-37) due to additive and unpredictable immune stimulation
- -May alter immune response dynamics in individuals on chemotherapy—timing relative to cytotoxic agents should be carefully managed
- -Patients with autoimmune conditions (e.g., lupus, rheumatoid arthritis) should avoid use due to risk of immune overactivation
Cost & Where to Buy
Pricing reflects research-grade lyophilized peptide from peptide vendors, typically sold in 1–5mg vials. Monthly cost depends on dosing frequency and vendor quality; pharmaceutical-grade or compounded preparations will be significantly more expensive. Availability may be limited compared to more mainstream peptides.
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